D&C Red No. 27 The color additive is manufactured by brominating 4,5,6,7- tetrachlorofluorescein with elemental bromine. The FDA has stated that "D&C Red No. 27 may be safely used for coloring drugs generally in amounts consistent with current good manufacturing practice." Manufacturing practices that limit the abouts of Lead, Arsenic, Mercury and bromate. Bromate was first found to cause tumors in rats in 1982. Subsequent studies on rats and mice confirmed that it causes tumors of the kidney, thyroid, and other organs. Instead of banning bromate, since 1991 the FDA, with only partial success,has urged bakers to voluntarily stop using it. The Center for Science in the Public Interest petitioned the Food and Drug Administration (FDA) to prohibit the use of potassium bromate, which is used to strengthen bread dough. http://vm.cfsan.fda.gov & www.cspinet.org A lake is a solid, non water soluble form of a dye. It's produced by mixing the dye with Aluminum Hydroxide. By itself Aluminum Hydroxide is a safe food ingredient and it's often sold as an antacid. When combined with Dye, the chemicals form a deep powder that can be applied to the outsides of tablets, gumballs and other solids. You may also notice this form listed in the ingredients as "Aluminum Lake"