ingredient information
Nitrous Oxide
Nitrous oxide is an anesthetic gas. It is used during dental work and with patients who are not candidates for more commonly used anesthetics during surgery. Interactions with Dietary Supplements Folic acid and Vitamin B12 Nitrous oxide interferes with activity of vitamin B12, which further interferes with the activity of folic acid, causing adverse actions.1 2 Administration of folic acid or folinic acid (activated folic acid) has reversed nitrous oxide-induced bone marrow changes.3 4 People with vitamin B12 deficiency may be especially susceptible.5 People who will undergo nitrous oxide anesthesia for several hours may benefit from vitamin B12 and folic acid supplementation.6 Some doctors recommend 100 mcg of vitamin B12 and 1,000 mcg folic acid, starting one week before through one week after prolonged exposure to nitrous oxide. People with normal vitamin B12 levels who undergo short-duration nitrous oxide anesthesia (less than two hours) do not require supplementation